Mayer also cites the coffee-can portfolio approach to help investors resist selling early. Explaining the strategy, he advises readers to pick a compelling story, leader or country and be willing to risk everything in their ‘coffee cans’ for it. Mayer illustrates this through the story of how, in 1987, equal amounts were invested in high-tech and bio-tech firms that held great potential. However, nine sunk without a trace; bio-tech firm Amgen, on the other hand, returned 800x by 1994, making up for the losses in the others. Mayer recommends not experimenting with start-ups but focusing on well-established companies with long runways of growth. Mayer insists that great investors do not worry about unknowable or unpredictable things such as the Fed rate or dollar or the overall state of the markets. Instead, they focus on great opportunities.