Innovation first begins as a figment of imagination because someone wants to create something that has not been tried before. Rapidly changing technology and associated uncertainty ensure a high failure rate. Yet, breakthrough innovation has time and again altered human life for the better. The United States, home to Silicon Valley, continues to lead innovation with companies collectively spending over $145 billion in 2015 on research and development. It is no wonder that every breakthrough technology owes its origin to some Valley start-up.